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Better platelet function, less fibrinolysis and less hemolysis in re-transfused residual pump blood with the Ringer's chase technique: a randomized pilot study
Blekinge Inst Technol, Dept Hlth Sci, Vallhallavagen 1, S-37179 Karlskrona, Sweden.;Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden.;Blekinge Hosp, Dept Cardiothorac Surg, Karlskrona, Sweden..
Linkoping Univ, SWE.
Linkoping Univ, SWE.ORCID-id: 0000-0002-1920-3962
Linkoping Univ, SWE.
Vise andre og tillknytning
2018 (engelsk)Inngår i: Perfusion, ISSN 0267-6591, E-ISSN 1477-111X, Vol. 33, nr 3, s. 185-193Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Introduction: Residual pump blood from the cardiopulmonary bypass (CPB) circuit is often collected into an infusion bag (IB) and re-transfused. An alternative is to chase the residual blood into the circulation through the arterial cannula with Ringer's acetate. Our aim was to assess possible differences in hemostatic blood quality between these two techniques. Methods: Forty adult patients undergoing elective coronary artery bypass graft surgery with CPB were randomized to receive the residual pump blood by either an IB or through the Ringer's chase (RC) technique. Platelet activation and function (impedance aggregometry), coagulation and hemolysis variables were assessed in the re-transfused blood and in the patients before, during and after surgery. Results are presented as median (25-75 quartiles). Results: Total hemoglobin and platelet levels in the re-transfused blood were comparable with the two methods, as were soluble platelet activation markers P-selectin and soluble glycoprotein VI (GPVI). Platelet aggregation (U) in the IB blood was significantly lower compared to the RC blood, with the agonists adenosine diphosphate (ADP) 24 (10-32) vs 46 (33-65), p<0.01, thrombin receptor activating peptide (TRAP) 50 (29-73) vs 69 (51-92), p=0.04 and collagen 24 (17-28) vs 34 (26-59), p<0.01. The IB blood had higher amounts of free hemoglobin (mg/L) (1086 (891-1717) vs 591(517-646), p<0.01) and D-dimer 0.60 (0.33-0.98) vs 0.3 (0.3-0.48), p<0.01. Other coagulation variables showed no difference between the groups. Conclusions: The handling of blood after CPB increases hemolysis, impairs platelet function and activates coagulation and fibrinolysis. The RC technique preserved the blood better than the commonly used IB technique.

sted, utgiver, år, opplag, sider
SAGE PUBLICATIONS LTD , 2018. Vol. 33, nr 3, s. 185-193
Emneord [en]
cardiopulmonary bypass, methods, hemostasis, platelet function tests
HSV kategori
Identifikatorer
URN: urn:nbn:se:bth-16119DOI: 10.1177/0267659117733891ISI: 000429907500003PubMedID: 28950757OAI: oai:DiVA.org:bth-16119DiVA, id: diva2:1201726
Tilgjengelig fra: 2018-04-26 Laget: 2018-04-26 Sist oppdatert: 2018-04-26bibliografisk kontrollert

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