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Cytokine and microbial profiles in relation to the clinical outcome following treatment of peri-implantitis
Blekinge Institute of Technology, Faculty of Engineering, Department of Health.
Kristianstad Univ., SWE.
Kristianstad Univ., SWE.
2017 (English)In: Clinical Oral Implants Research, ISSN 0905-7161, E-ISSN 1600-0501, Vol. 28, no 9, 1127-1132 p.Article in journal (Refereed) Published
Abstract [en]

Aim: To study whether cytokine levels and bacterial counts in p atients with peri-implantitis reflect clinical treatment outcome following non-surgical management. Materials and Methods: Luminex magnet bead technology and checkerboard DNA-DNA hybridization were used to assess treatment outcome after treatment at the implant with the most severe peri-implantitis in 41 participants. Results: Study group mean age was 40.3 years (SD ± 9.9). Stable treatment outcome after 6 months (no further bone loss, probing pocket depth decrease ≥0.5 mm, no bleeding/suppuration) was identified in 9 of 41 (22%) participants. Peri-implant crevicular fluid (PICF) levels were also lower for Il-1β (P < 0.01), and with trends of lower cytokine levels in PICF for TNF-α (P = 0.071), PDGFBB (P = 0.071), as well as for VEGF (vascular endothelial growth factor) (P = 0.071), and bacterial counts for Actinomyces israelii, Aggregatibacter actonomycetemcomitans (Y4), Campylobacter gracilis, Echerichia coli, Fusobacterium periodonticum, Leptotrichia buccalis, Parvimonas micra, Staphylococcus haemolyticus, Streptococcus anginosus, and Tannerella forsythia. Increasing levels of IL-1 β and S. aureus (r2 = 0.856) were found only at implants with non-stable outcome. A reduction of PICF levels for selected cytokines and bacteria studied had a sensitivity of 0.77, and a specificity of 0.80 against the clinical outcome as gold standard. Data analysis failed to differences in treatments (PerioFlow® versus YAG: ER laser) for changes in the expression of cytokines and bacteria studied. Conclusions: At 6 months, clinically stable treatment outcome of peri-implantitis is associated lower levels of putative pathogens total bacterial load with ≥30% reduction of IL1-β, L-6, and VEGF levels in PICF.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2017. Vol. 28, no 9, 1127-1132 p.
Keyword [en]
Bacteria, Dental implant, Human, Pro-inflammatory marker
National Category
Dentistry
Identifiers
URN: urn:nbn:se:bth-13493DOI: 10.1111/clr.12927ISI: 000409448600020Scopus ID: 2-s2.0-84994144984OAI: oai:DiVA.org:bth-13493DiVA: diva2:1049337
Available from: 2016-11-24 Created: 2016-11-23 Last updated: 2017-10-05Bibliographically approved

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