This study aims to propose a decision support system based on optimization modelling for operating room resource planning and sequence dependent scheduling of surgery operations. We conduct a simulation experiment using real world data collected from the local hospital to evaluate the proposed model. The obtained results are compared with real surgery schedules, planned at the local hospital. The experiment shows that the efficiency of schedules produced by the proposed model are significantly improved, in terms of less surgery turnover time, increased utilization of operating rooms and minimized make-span, compared to the real schedules. Moreover, the proposed optimization based decision support system enables analysis of surgery scheduling in relation to resource planning.