There is a need for large-scale and coordinated leadership and innovation to transform society toward sustainability. Working from the Strategic Sustainable Development (SSD) approach, the authors investigated the potential of enterprise education and curriculum design in promoting Transformational Innovation toward Sustainability (TIS). A five phase qualitative research design was created, consisting of 17 semi-structured interviews with experts, and 4 case studies with leading enterprise education institutions. The results consisted of a framework including an articulation of a holistic and systemic paradigm; a description of the structure and qualities of the purpose, vision, and final aims that should guide a curriculum; a list of 7 competences that should be trained and developed within the curriculum; a list of 9 virtues that should be cultivated within the curriculum; and 3 pedagogical principles to inform the delivery of the curriculum and pedagogy. The study has made two contributions to the field and practice of SSD: an articulation and unfolding of the Transformational Innovation toward Sustainability (TIS) concept, and a framework and set of recommendations to inform their work in training future entrepreneurs and innovators to lead transformative innovation processes towards sustainability. 

KEY WORDS: Curriculum Design, Transformative Learning, Transformative Innovation, Sustainability, Strategic Sustainable Development, Education for Sustainability