Architecting software systems according to the service-oriented paradigm, and designing runtime self-adaptable systems are two relevant research areas in today’s software engineering. In this chapter we present MOSES, a software platform supporting QoS-driven adaptation of service-oriented systems. It has been conceived for service-oriented systems architected as composite services that receive requests generated by different classes of users. MOSES integrates within a unified framework different adaptation mechanisms. In this way it achieves a greater flexibility in facing various operating environments and the possibly conflicting QoS requirements of several concurrent users. Besides providing its own self-adaptation functionalities, MOSES lends itself to the experimentation of alternative approaches to QoS-driven adaptation of service-oriented systems thanks to its modular architecture. © Springer International Publishing AG 2017.