We take selective stock of the literature on the geography of entrepreneurship. This literature has been focused on rates of new firm formation, whereas studies of the geography of “high-impact” entrepreneurship are still scant. Entrepreneurship may be described as a “regional event” by the fact that entrepreneurs derive necessary resources from local markets, but also from regional spillovers, social networks, and engrained factors of the local industrial geography. We point to a few fields of analysis where causal or more detailed analyses are warranted.