Abstract.Background: A randomized controlled trial of the SMART4MD tablet application was conducted for persons with mildcognitive impairment (PwMCI) and their informal caregivers to improve or maintain quality of life.Objective: The objective was to conduct economic evaluation of SMART4MD compared to standard care in Sweden froma healthcare provider perspective based on a 6-month follow-up period.Methods: Three hundred forty-five dyads were enrolled: 173 dyads in the intervention group and 172 in standard care. Theprimary outcome measures for PwMCI and informal caregivers were quality-adjusted life years (QALY). The results arepresented as incremental cost-effectiveness ratios, and confidence intervals are calculated using non-parametric bootstrapprocedure.Results: For PwMCI, the mean difference in total costs between intervention and standard care was D 12 (95%CI: –2090to 2115) (US$ = D 1.19) and the mean QALY change was –0.004 (95%CI: –0.009 to 0.002). For informal caregivers, thecost difference was – D 539 (95%CI: –2624 to 1545) and 0.003 (95%CI: –0.002 to 0.008) for QALY. The difference in costand QALY for PwMCI and informal caregivers combined was –D 527 (95%CI: –3621 to 2568) and –0.001 (95%CI: –0.008to 0.006). Although generally insignificant differences, this indicates that SMART4MD, compared to standard care was: 1)more costly and less effective for PwMCI, 2) less costly and more effective for informal caregivers, and 3) less costly andless effective for PwMCI and informal caregivers combined.∗Correspondence to: Zartashia Ghani, PhD-Candidate, AppliedHealth Technology, Department of Health, Blekinge Institute ofTechnology, Lumavagen 1, 371 50 Karlskrona, Sweden. Tel.: ¨0046733420237; E-mail: zartashia.ghani@bth.se.ISSN 1387-2877 © 2022 – The authors. Published by IOS Press. This is an Open Access article distributed under the termsof the Creative Commons Attribution-NonCommercial License (CC BY-NC 4.0).1630 Z. Ghani et al. / Short Term Economic Evaluation of the Digital Platform (SMART4MD)Conclusion: The cost-effectiveness of SMART4MD over 6 months is inconclusive, although the intervention might be morebeneficial for informal caregivers than PwMCI.