Aim: To explore nursing students’ experiences of applying problem-based learning to train the core competence teamwork and collaboration. Design: The study used a qualitative descriptive design. Method: The data were collected using individual interviews with a purposive sample of 11 students and analysed using inductive qualitative content analysis. Results: The students’ experiences of applying problem-based learning to train the core competence teamwork and collaboration were described in two generic categories: prerequisites to train teamwork and collaboration and abilities practised in the base group. The generic category “prerequisites to train teamwork and collaboration” includes three subcategories: previous experience and education, composition of the base group, and common goals and values in the base group. The generic category “abilities practised in the base group” includes four subcategories: taking personal responsibility, practising role distribution and leadership, developing communication skills and creating togetherness in the base group.