Today different transport modes use to deliver cargo between regions, from ports to final destination location or visa-versa. It is quite common to use road transport, which can deliver cargo “from door to door” but road transport causes big environmental impact. Considering alternative possibilities (road, railway and/or inland waterway transport) to decrease environmental impact from transport, it is very important. Based on theoretical and experimental tests, were find optimal solutions, which transport mode make minimum environmental impact and could be the most technically and economically effective solution. Traffic congestion on the roads, in some cases very high railway traffic in some regions, generates requirements by many stakeholders on ways to decrease the environmental impact from transport modes, which studded in Article to find and identify optimal transportation solutions with minimum environmental impact. A theoretical method evaluation conducted on the optimal transportation possibility that minimizes environmental impact. A transport modes environmental comparative index (ECI) is developed and used for evaluations. This paper presents possible alternative transportation conditions based on multi-criteria evaluation system, proposes theoretical basis for the optimal solutions from environmental and economic point of view, and provides for experimental testing during the specific case study, and finally provides recommendations and conclusions. © 2022 The Authors.