To contribute to deeper learning about innovation towards sustainability, we must acknowledge that all innovations have directionality as well as be clear about what and for whom our sustainability discussions concern. Whatever consequences of innovation result, it implicates reality production. The frames of my understanding are developed within feminist technoscience linked to practitioners and writers of mode 2 knowledge production. I use epistemological considerations for theories and methodologies to understand and broaden knowledge and practices within the field of Innovation and Development. How can feminist technoscience and other research areas, which involve a critical view of research-development-innovation, mobilize the transformative potential needed for sustainable conditions, especially in scarce resources contexts?