Optimizing healthcare systems has become more crucial in recent years due to escalating healthcare demands and economic constraints. This dissertation employed industrial economic principles and advanced statistical methods to analyze the performance and efficiency of healthcare systems in Europe. The study provided a detailed analysis of how healthcare systems can enhance service delivery and maintain cost-effectiveness by integrating industrial economic theories with empirical data. The dissertation was organized into a series of analyses, each focusing on different aspects of healthcare system performance, resource allocation, operational efficiency, and forecasting future health demands, as well as evaluating the accuracy of these forecasting models. Statistical techniques such as time series and multilevel regression analyses were used to examine the interplay between healthcare resources, healthcare systems, and health outcomes across European nations. The two main healthcare models in Europe, the Beveridge and Bismarck models, were compared in terms of performance, efficiency, and resource allocation. The main findings revealed that effective resource allocation and efficient management practices can significantly enhance the performance of healthcare systems. The study indicated that a healthcare system's efficiency depends on its ability to adjust resource allocation to changes in demographic and economic conditions. Additionally, this dissertation forecasted future demands for healthcare services, social security benefits, and pensions by incorporating macro-level determinants such as economic growth, unemployment rates, and population density into the forecasting models. The accuracy of these models provided valuable insights for policymakers to effectively plan for future healthcare, social security, and pension needs. Moreover, this dissertation employed an economic evaluation to compare the cost-effectiveness of Beveridge-type and Bismarck-type healthcare systems over the past twenty years. An effectiveness ratio was applied to measure the relationship between inputs (medical spending) and outputs (health outcomes). These effectiveness ratios demonstrated which healthcare system yields better health outcomes for each dollar spent. Furthermore, the findings indicated that the efficiency of healthcare systems varies from country to country, highlighting the challenges of adopting a universal approach to healthcare policy. This dissertation contributes to the academic field by demonstrating how industrial economic principles can be applied to improve the performance and efficiency of healthcare systems. It offered a framework for evaluating healthcare performance and efficiency, which can inform future reforms to achieve sustainable, high-quality healthcare services. This study promotes a dynamic approach to healthcare planning that adapts to technological advancements and demographic changes to enhance population health.