Non-profit organizations are an indivisible part of the structure of today’s economy, the good they offer are rarely discountenanced, yet they face multiple problems that threaten the traditional foundations of their operations. Projects run by these organizations face new measurement metrics that streamlines how funds are subsequently obtained, they face stiff competition from counterpart organizations who strive to outdo each other for funds needed for programs and it is common place to see governments grant focus change with attendant change in the disbursement of funds. These dynamics place extra demand on non-profit organizations to be relevant in terms of programs and also to constantly re-strategize in the event that prior guaranteed funds are no longer accessible. Taking a cue from the models and theories of entrepreneurship, network systems and dynamic capabilities; projected as the framework for understanding how these non-profit organizations can sustain operations and remain relevant, the research work in this thesis seeks empirical evidence from the field in order to determine if the theories projected have the possibility of being applied in the operations of the non-profit sector.