“When in Rome do as the Romans do” – this hundreds years old proverb is still very actual today. Even more, nowadays you don’t even have to go to Rome to feel cultural differences. The communication technology have changed the world economy, thousands of people work now for multinational companies, interacting daily not just with a culture, but possibly with as much as 5 or 6 different ones. Some teams even work in different geographical locations communicating exclusively by electronic means. Today’s managers just have to deal with culture whether they like it or not, but the whole employee-manager relationship may be turned upside down on another side of the globe. So what should we do and what do we do about it? Ho do we manage effectively? These are the questions that this study aims to answer at. The main research objects of this study are rather small software engineering teams and companies that are working in cross-cultural environment, but do have little or no special company policies and other formal ways to manage cultural differences. Yet we found out that managers develop there own understanding of cultural issues and are practicing different methods to deal with them.