Through this thesis the authors explore how Labs can be designed in order to catalyze systemic sustainable change by A) contributing to systemic socio-ecological sustainability, B) providing an adaptive and experimental alternative to forecasting and traditional planning, and C) providing forums for collaboration, collective impact, capacity building, and the emergence of systemic solutions to local and global challenges. Through their research the authors performed a literature/field review, reviewed organizational documents, and analyzed a select set of Lab theories, processes, and cases. Additionally the authors interviewed leading experts in Lab design/facilitation, sustainability, the Framework for Strategic Sustainable Development (FSSD), systemic change, and transformative action. The synthesis of this research is offered to emerging Lab designers, practitioners, and facilitators interested in moving society toward a sustainable, regenerative, and thriving future.