The evolved version of LTE is LTE-Advanced which is being developed by 3GPP. LTE-Advanced will meet or go beyond the requirements of the International Telecommunication Union (ITU) for the fourth generation (4G) radio communication standard known as IMT-Advanced. LTEAdvanced is primarily considered as a part of Release 10 of 3GPP specifications. The LTE-Advanced specifications will continue to be developed in subsequent 3GPP releases. The complete physical layer structure has been employed by using the latest 3GPP standards. Furthermore, technologies such as Orthogonal Frequency Division Multiplexing (OFDM) and Multiple Input Multiple Output (MIMO) have also been implemented and integrated with LTEAdvanced. The Multiple Access Scheme in Advanced Mobile radio system has to meet the specific requirements such as: high throughput, robustness, efficient Bit Error Rate (BER), high spectral efficiency, minimum delays, low computational complexity, low Peak to Average Power Ratio (PAPR), low error probability etc. In order to investigate the LTE-Advanced transceiver a thorough study has been carried out using MATLAB Simulink using AWGN and Rayleigh fading channel. This report investigates the performance of OFDMA and various MIMO configurations of LTEAdvanced physical layer, along with diverse modulation techniques such 16QAM and QPSK,the results are then demonstrated on BER and signal to noise ratio graphs. AWGN and Rayleigh fading models are also used to determine the performance of LTE-Advanced in presence of noise and fading.