The purpose of this research of this paper was to find the bank deposit on the performance of the listed banks on the Ghana Stock Exchange for a five year period from 2005 – 2009. Using a multiple regression analysis, a correlation analysis was first estimated to test for the presence of multi collinearity among the independent variables. The study found debt, size, deposits, equity and the type of bank ownership as significant indicators that contribute to the performance of the listed banks measured as the returns on equity and returns on assets of listed banks on the Ghana Stock Exchange