In this thesis, I examined various signalling both in wired and mobile networks, with more emphasis on SIGTRAN. The SIGTRAN is the protocol suite applicable in the current new generation and next-generation networks, most especially as it enables service provider to be able to interpolate both wireline and wireless services within the same architecture. This concept is an important component in today’s Triple-play communication, and hence this thesis has provided a broad view on Signalling and Protocol Gateways in Traditional and Next Generations Networks. Signal flow in a typical new generation network was examined by carrying out discrete event simulation of UMTS network using OPNET modeller 14.5. Through both Packet-Switching (PS) and Circuit-Switching (CS) signalling, I was able to examine the QoS on a UMTS. Precisely, I looked at throughput on UMTS network by implementing WFQ and MDRR scheduling schemes.