In-home healthcare services based on the Internet-of-Things (IoT) have great business potential; however, a comprehensive platform is still missing. In this paper, an intelligent home-based platform, the iHome Health-IoT, is proposed and implemented. In particular, the platform involves 1) an open-platform-based intelligent medicine box (iMedBox) with enhanced connectivity and interchangeability for the integration of devices and services, 2) intelligent pharmaceutical packaging (iMedPack) with communication capability enabled by passive radio-frequency identification (RFID) and actuation capability enabled by functional materials, and 3) flexible and wearable bio-medical sensor device (Bio-Patch) enabled by the state-of-the-art inkjet printing technology and system-on-chip. The proposed platform seamlessly fuses IoT devices (e.g., wearable sensors, intelligent medicine packages, etc.) with in-home healthcare services (e.g., telemedicine) for an improved user experience and service efficiency. The feasibility of the implemented iHome Health-IoT platform has been proven in field trials.