Systematic leadership towards sustainability implies utilization of systems thinking for step-wise approaches to transformative changes towards sustainable societies. This ‘call-for-papers’ (CfPs) for a Special Volume of the Journal of Cleaner Production is focused upon what types of research are needed for us to make the necessary local, regional, national and global changes. This CfPs is for anyone who wishes to address these challenges seriously, that is, to utilize essential aspects of leadership to contribute strategically to the transition towards sustainable societies. To successfully address these challenges, people from different sectors and disciplines must work together in a coordinated and efficient way. We wish to explore the question: What support do such transformative endeavors require and how can science contribute?