Comprehensive communication in cognitive radio networks is an important research topic within the scope of empowering cognitive radio functionality in beyond-4G mobile networks. Providing communication for secondary users without interference with primary users is an ambitious task, which requires innovative management architecture designs and routing solutions. Operational challenges such as opportunistic spectrum access, solving problems related to spectrum and network heterogeneities and requests for the provisioning of Quality-of-Service to different applications must be resolved. As part of a novel management architecture, the paper advances a new approach to end-to-end communication in cognitive radio networks based on combining ad-hoc algorithms with spectrum mobility algorithms.