The main purpose of this thesis is to investigate potential synergies between an electronic waybill (e-Waybill) and other Intelligent Transport System (ITS) services. An e-Waybill service, as presented in this thesis, should be able to perform the functions of a paper waybill (which is an important transport document and contains essential information about a consignment) and it should contain at least the information specified in a paper waybill. To investigate synergies between the e-Waybill solutions and ITS services, we present 5 conceptual e-Waybill solutions that differ in where the e-Waybill information is stored, read, and written. These solutions are further investigated for functional and technical requirements (non-functional requirements), which can potentially impose constraints on a potential system that should implement the e-Waybill service. A set of 20 ITS services are considered for synergy analysis in this thesis. These services are mainly for road transport, however most of them are relevant to be considered for utilization in other modes of transport as well. For information synergy analysis, the e-Waybill solutions are assessed based on their synergies with ITS services. For different ITS services, the required input information entities are identified; and if at least one information entity can be provided by an e-Waybill at the right location we regard it to be a synergy. The result from our synergy analysis may support the choice of practical e-Waybill systems, which has the possibility to provide high synergy with ITS services. This may lead to a higher utilization of ITS services and more sustainable transport, e.g., in terms of reduced congestion and emissions. Additionally, a service design method has been proposed for supporting the process of designing new ITS services, which primarily utilizes on functional synergies with already existing ITS services. In order to illustrate the usage of the suggested method, we have applied it for designing a new ITS service, i.e., the Liability Intelligent Transport System (LITS) service. The purpose of the LITS service is to support the process of identifying when, where, and by whom a consignment has been damaged and who was responsible when the consignment was damaged.