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Systemic antibiotics and debridement of peri-implant mucositis. A randomized clinical trial
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2012 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979 , Vol. 39, no 6, 574-581 p.Article in journal (Refereed) Published
Abstract [en]

Background This RCT compared non-surgical treatment of peri-implant mucositis with or without systemic antibiotics. Materials and Methods Forty-eight subjects received non-surgical debridement with or without systemic Azithromax (R) (4 similar to days), and were followed during 6 similar to months. The checkerboard DNA-DNA hybridization method was used to analyse the microbiological material. Results Five subjects were excluded due to antibiotic medication during follow-up. At baseline,1 and 3 similar to months no group differences were found. Statistical analysis failed to demonstrate differences in probing pocket depths (PPD) values at 6 similar to months (Mean diff PPD: 0.5 similar to mm, SE: +/- 0.4 similar to mm, 95% CI: -0.2, 1.3, p similar to 0.16). Mean% implant bleeding decreased between baseline and month 6 from 82.6% to 27.3% in the test, and from 80.0% to 47.5% in the control group (p similar to 0.02). Throughout the study, no study group differences in bacterial counts were found. Conclusion No short-term differences were found between study groups. The clinical improvements observed at 6 similar to months may be attributed to improvements in oral hygiene. The present study does not provide evidence for the use of systemic antibiotics in treatment of peri-implant mucositis.

Place, publisher, year, edition, pages
Wiley Blackwell , 2012. Vol. 39, no 6, 574-581 p.
Keyword [en]
antibiotics, microbiology, peri-implant disease, peri-implant mucositis, therapy
National Category
Medical and Health Sciences
URN: urn:nbn:se:bth-7143DOI: 10.1111/j.1600-051X.2012.01884.xISI: 000303855200009Local ID: diva2:834725
Available from: 2012-11-29 Created: 2012-11-29 Last updated: 2015-06-30Bibliographically approved

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Renvert, Stefan
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