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A single-centre randomized controlled clinical trial on the adjunct treatment of intra-bony defects with autogenous bone or a xenograft: results after 12 months
Blekinge Institute of Technology, School of Health Science.
2012 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979 , Vol. 39, no 7, 666-673 p.Article in journal (Refereed) Published
Abstract [en]

Background Limited evidence exists on the efficacy of regenerative treatment of peri-implantitis. Material and Methods Subjects receiving antibiotics and surgical debridement were randomly assigned to placement of autogenous bone (AB) or bovine-derived xenograft (BDX) and with placement of a collagen membrane. The primary outcome was evidence of radiographic bone fill and the secondary outcomes included reductions of probing depth (PD) bleeding on probing (BOP) and suppuration. Results Twenty-two subjects were included in the AB and 23 subjects in the BDX group. Statistical analysis failed to demonstrate differences for 38/39 variables assessed at baseline. At 12 months, significant better results were obtained in the BDX group for bone levels (p < 0.001), BOP (p = 0.004), PI (p = 0.003) and suppuration (p < 0.01). When adjusting for number of implants treated per subject, a successful treatment outcome PD = 5.0 mm, no pus, no bone loss and BOP at 1/4 or less sites the likelihood of defect fill was higher in the BDX group (LR: 3.2, 95% CI: 1.010.6, p < 0.05). Conclusions Bovine xenograft provided more radiographic bone fill than AB. The success for both surgical regenerative procedures was limited. Decreases in PD, BOP, and suppuration were observed.

Place, publisher, year, edition, pages
Wiley Blackwell , 2012. Vol. 39, no 7, 666-673 p.
Keyword [en]
antibiotics, bone grafting, peri-implant disease, peri-implantitis, surgical therapy
National Category
Medical and Health Sciences
URN: urn:nbn:se:bth-7168DOI: 10.1111/j.1600-051X.2012.01880.xISI: 000305130000009Local ID: diva2:834750
Available from: 2012-11-27 Created: 2012-11-27 Last updated: 2015-06-30Bibliographically approved

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Renvert, Stefan
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