The intelligent multi-sensor system is a system for target detection, identification and information processing for human activities surveillance and ambient assisted living. This paper describes RFID multi-target tracking using the Gaussian Mixture Probability Hypothesis Density, GM-PHD, algorithm. The multi target tracking ability of the proposed solution is demonstrated in a simulation and real environment. A performance comparison of the Levenberg-Marquardt algorithm with and without the GM-PHD filter shows that the GM-PHD algorithm improves the accuracy of tracking and target position estimation significantly. This improvement is demonstrated by a simulation and by a physical experiment.