In this paper, we propose a cross-layer optimization approach for replication of video streaming over multihop wireless network by jointly taking into account application, network, medium access control, and physical layers. Specifically, we design a middleware replication strategy layer with a stack profile, in which parameters across the hops and all considered layers are exchanged for optimal video replication. The simulation results demonstrate that our method improves the replication strategy performance in terms of user-perceived video quality. In turn, it satisfies the heterogeneous receive bandwidth constraint of users for efficiently using the network bandwidth compared to other optimal replication strategies without cross-layer approach.