To predict which supply chain effects will appear when applying governmental control policies, infrastructure investments, and business strategies, multi-agent-based simulation (MABS) can be used. In this paper, we identify abstract supply chain responsibilities, roles and interactions that are argued to be sufficient for representing all types of organizations involved in the processes of buying and selling products and transport services. The identified responsibilities, roles and interactions are organized into a framework together with a set of modeling guidelines, which we relate to the GAIA methodology to simplify the process of developing multi-agent-based supply chain simulation models. To illustrate the usage of the framework, we provide two case studies where we apply it to two different MABS models.