Abstract: e-Health has been one of the most expected IT (information technology) applications just like e-Business, e-Learning, e-Government, and e-Democracy. However, e-Health has not reached the expected scale of use IT. There are challenges especially involved in healthcare sectors that are so different from other sectors. I will stress those challenges and suggest some approaches to meet the challenges from my past 10 years experience as a researcher in this area. I hope this will provide with researchers, entrepreneurs, and practitioners some hints when e-Health is the target area.