Region of interest (ROI) coding is a feature supported by the Joint Photographic Experts Group 2000 (JPEG2000) image compression standard and allows particular regions of interest within an image to be compressed at a higher quality than the rest of the image. In this paper, unequal error protection (UEP) is proposed for ROI coded JPEG2000 images as a technique for providing increased resilience against the effects of transmission errors over a wireless communications channel. The hierarchical nature of an ROI coded JPEG2000 code-stream lends itself to the use of UEP whereby the important bits of the code-stream are protected with a strong code while the less important bits are protected with a weaker code. Simulation results obtained using symbol-by-symbol maximum a posteriori probability (MAP) decoding demonstrate that the use of UEP offers significant gains in terms of the peak signal to noise ratio (PSNR) and the percentage of readable files. Moreover, the use of ROI-based UEP leads to reduced computational complexity at the receiver.