We examine the impact of clusters of primary transceivers in cognitive multiple-input multiple-output (MIMO) relay networks with underlay spectrum sharing. In such a network, we propose antenna selection as an interference-aware design to satisfy the power constraints in the primary and secondary networks. To demonstrate this, we consider transmit antenna selection with maximal ratio combining (TAS/MRC) in the primary and secondary networks. With this in mind, we derive new closed-form asymptotic expressions for the outage probability and the symbol error rate (SER) over independent Nakagami-m fading channels. Our results lead to several new fundamental insights. In particular, we highlight that TAS/MRC achieves a full diversity gain when the maximum transmit power in the secondary network is proportional to the peak interference temperature in the primary network.