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  • 1.
    Beiranvand, Samira
    et al.
    Ahvaz Jundishapur Univ Med Sci, IRN.
    Zarea, Kourosh
    Ahvaz Jundishapur Univ Med Sci, IRN.
    Ghanbari, Saeed
    Shiraz Univ Med Sci, IRN.
    Tuvesson, Hanna
    Blekinge Institute of Technology, Faculty of Engineering, Department of Health.
    Keikhaei, Bijan
    Ahvaz Jundishapur Univ Med Sci, IRN.
    Ten years incidence of cancer in Iran: a systematic review and meta-analysis2018In: CLINICAL EPIDEMIOLOGY AND GLOBAL HEALTH, ISSN 2452-0918, Vol. 6, no 2, p. 94-102Article, review/survey (Refereed)
    Abstract [en]

    Background: Designing and implementation of screening programs depend on greatly epidemiologic basic data in every country. Also Variation in the incidence of various cancers in our country has been a favorite topic. Objectives: This systematic review was conducted to provide an overall perspective about incidence, geographical and age distribution of cancers in Iran. Methods: A comprehensive search were done according to MOOSE guideline criteria in national and international databases for selecting eligible articles from 2005 to 2015. After screening titles and abstracts, duplicated and irrelevant studies were excluded. Selected papers are written in Persian or English. The standard error of the cancer incidence was calculated based on the binomial distribution. Because of the significant heterogeneity observed among the results, we used a random-effects model combine the results of the primary studies. Moreover, a sensitivity analysis was undertaken to explore the effects of the risk of bias and other sources of heterogeneity. Results: Overall 16 articles met eligibility criteria for inclusion. The total incidence of cancer was 19.4 and 17.2 per hundred thousand of people in males and females respectively. The five most common cancers in male were: Lymphoma, leukemia, esophagus, stomach, colorectal and in the female are: breast, colorectal, stomach, thyroid and esophagus. The highest incidence rate was seen in Golestan Province and in the age group over 65 years. Conclusion: According to increasing incidence rate of cancers in Iran, Development, holding and accomplish of universal public cancer control program should be the first precedence for health policy. (c) 2017 Published by Elsevier, a division of RELX India, Pvt. Ltd on behalf of INDIACLEN.

  • 2. Forssell, Henrik
    et al.
    Wester, Michael
    Åkesson, Katrin
    Johansson, Sigrid
    Blekinge Institute of Technology, School of Health Science.
    A proposed model for prediction of survival based on a follow-up study in unresectable pancreatic cancer2013In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 3, no 12, p. 1-6Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: To define an easy-to-use model for prediction of survival time in patients with unresectable pancreatic cancer in order to optimise patient' care. DESIGN: An observational retrospective study on patients with unresectable pancreatic cancer. The initial radiographs at presentation of symptoms were reviewed and the maximum diameter of the primary tumour was determined. The occurrence of liver metastases and performance status that determines initiation of chemotherapy was also used in the regression analysis to identify prognostic subgroups. SETTING: County hospital in south-east of Sweden. POPULATION: Consecutive patients with unresectable pancreatic cancer who were diagnosed between January 2003 and May 2010 (n=132). MAIN OUTCOME MEASURES: Statistical analyses were performed using Stata V.13. Survival time was assessed with Kaplan-Meier analysis, log-rank test for equality of survivor functions and Cox regression for calculation of individual hazard based on tumour diameter, presence of liver metastases and initiation of chemotherapy treatment according to patient performance status. RESULTS: The individual hazard was log h=0.357 tumour size+1.181 liver metastases-0.989 performance status/chemotherapy. Three prognostic groups could be defined: a low-risk group with a median survival time of 6.7 (IQR 9.7) months, a medium-risk group with a median survival time of 4.5 (IQR 4.5) months and a high-risk group with a median survival time of 1.2 (IQR 1.7) months. CONCLUSIONS: The maximum diameter of the primary tumour and the presence of liver metastases found at the X-ray examination of patients with pancreatic cancer, in conjunction with whether or not chemotherapy is initiated according to performance status, predict the survival time for patients who do not undergo surgical resection. The findings result in an easy-to-use model for predicting the survival time.

  • 3.
    Ola, Spjuth
    et al.
    Karolinska Institutet, SWE.
    Andreas, Karlsson
    Karolinska Institutet, SWE.
    Mark, Clements
    Karolinska Institutet, SWE.
    Keith, Humphreys
    Karolinska Institutet, SWE.
    Emma, Ivansson
    Karolinska Institutet, SWE.
    Jim, Dowling
    Royal Institute of Technology, SWE.
    Martin, Eklund
    Karolinska Institutet, SWE.
    Alexandra, Jauhiainen
    AstraZeneca AB R&D, SWE.
    Kamila, Czene
    Karolinska Institutet, SWE.
    Henrik, Grönberg
    Karolinska Institutet, SWE.
    Pär, Sparén
    Karolinska Institutet, SWE.
    Fredrik, Wiklund
    Karolinska Institutet, SWE.
    Abbas, Cheddad
    Blekinge Institute of Technology, Faculty of Computing, Department of Computer Science and Engineering.
    þorgerður, Pálsdóttir
    Nordic Information for Action e-Science Center, SWE.
    Mattias, Rantalainen
    Karolinska Institutet, SWE.
    Linda, Abrahamsson
    Karolinska Institutet, SWE.
    Erwin, Laure
    Royal Institute of Technology, SWE.
    Jan-Eric, Litton
    European Research Infrastructure Consortium, AUT.
    Juni, Palmgren
    Helsinki University, FIN.
    E-Science technologies in a workflow for personalized medicine using cancer screening as a case study2017In: JAMIA Journal of the American Medical Informatics Association, ISSN 1067-5027, E-ISSN 1527-974X, Vol. 24, no 5, p. 950-957Article in journal (Refereed)
    Abstract [en]

    Objective: We provide an e-Science perspective on the workflow from risk factor discovery and classification of disease to evaluation of personalized intervention programs. As case studies, we use personalized prostate and breast cancer screenings.

    Materials and Methods: We describe an e-Science initiative in Sweden, e-Science for Cancer Prevention and Control (eCPC), which supports biomarker discovery and offers decision support for personalized intervention strategies. The generic eCPC contribution is a workflow with 4 nodes applied iteratively, and the concept of e-Science signifies systematic use of tools from the mathematical, statistical, data, and computer sciences.

    Results: The eCPC workflow is illustrated through 2 case studies. For prostate cancer, an in-house personalized screening tool, the Stockholm-3 model (S3M), is presented as an alternative to prostate-specific antigen testing alone. S3M is evaluated in a trial setting and plans for rollout in the population are discussed. For breast cancer, new biomarkers based on breast density and molecular profiles are developed and the US multicenter Women Informed to Screen Depending on Measures (WISDOM) trial is referred to for evaluation. While current eCPC data management uses a traditional data warehouse model, we discuss eCPC-developed features of a coherent data integration platform.

    Discussion and Conclusion: E-Science tools are a key part of an evidence-based process for personalized medicine. This paper provides a structured workflow from data and models to evaluation of new personalized intervention strategies. The importance of multidisciplinary collaboration is emphasized. Importantly, the generic concepts of the suggested eCPC workflow are transferrable to other disease domains, although each disease will require tailored solutions.

  • 4.
    Wångdahl, Rebecka
    et al.
    Blekinge Institute of Technology.
    Jarl, Emelie
    Blekinge Institute of Technology.
    Kvinnors upplevelser av att leva med livmoderhalscancer: En litteraturstudie2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Bakgrund: Varje år får cirka 500 000 kvinnor beskedet livmoderhalscancer runt om i världen. Sjukdomen kan föra med sig komplikationer så som svårigheter med det sexuella livet och att bli gravid. Kvinnorna kan även få ångest inför framtiden och vara oroliga för återinsjuknande. Livmoderhalscancer är en ångestladdad sjukdom och sjuksköterskor behöver ökad förståelse för de frågor och tankar patienter upplever i samband med livmoderhalscancer.

    Syfte: Syftet med studien var att beskriva kvinnors upplevelser av att leva med livmoderhalscancer.

    Metod: Litteraturstudie med kvalitativ ansats. Data samlades in från olika sökoperatörer och analyserades med Graneheim och Lundmans tolkning av innehållsanalys.

    Resultat: Resultatet visade att livmoderhalscancer kan medföra oro för framtiden, ångest för återinsjuknande och rädsla för infertilitet. Kvinnorna beskrev också att vardagslivet och det sexuella livet påverkats av sjukdomen. Kvinnorna kände sig som en belastning för familjerna på grund av de rollförändringar som kunde ske i hemmet under sjukdomsförloppet. Det sexuella livet blev lidande av komplikationerna från behandlingen. Kvinnorna önskade mer information från vårdpersonal angående behandlingens bieffekter och ansåg dessutom att vårdpersonal borde visa mer medlidande. Kvinnorna upplevde inte stödet från vårdpersonal som tillfredställande utan såg familj och vänner som en viktig källa till stöd. Medpatienter ansågs även vara ett stort stöd då det var skönt att prata med någon i samma situation.

    Slutsats: Kvinnor som insjuknat i livmoderhalscancer upplever oro, ångest och rädsla. De upplevde förändringar i det sexuella- och vardagliga livet vilket fick dem att ifrågasätta sin kvinnliga identitet. Genom att uppmärksamma kvinnors upplevelser av livmoderhalscancer kan sjuksköterskan bidra till minskat lidande hos dessa kvinnor. Vårdpersonal bör ge kvinnor som insjuknat i livmoderhalscancer mer information om eventuella bieffekter från behandling för att öka kvinnors möjligheter att hantera sjukdomen.

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