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Bengtsson, V. W., Aoki, A., Mizutani, K., Lindahl, C. & Renvert, S. (2025). Treatment of peri-implant mucositis using an Er:YAG laser or an ultrasonic device: a randomized, controlled clinical trial. International Journal of Implant Dentistry, 11(1), Article ID 6.
Open this publication in new window or tab >>Treatment of peri-implant mucositis using an Er:YAG laser or an ultrasonic device: a randomized, controlled clinical trial
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2025 (English)In: International Journal of Implant Dentistry, E-ISSN 2198-4034, Vol. 11, no 1, article id 6Article in journal (Refereed) Published
Abstract [en]

Purpose

The study assessed the clinical outcomes following treatment of peri-implant mucositis using Er:YAG laser or an ultrasonic device over six months. Patients' experience of pain, aesthetics, and Quality of life were further assessed.

Methods

One dental implant, per included patient, diagnosed with peri-implant mucositis underwent treatment with an Er:YAG laser (test) or an ultrasonic scaler (control) randomly. Treatments were performed at baseline and months three and six. At each session, oral hygiene was instructed after plaque registration, and the patient was guided in proper cleaning technique using a toothbrush and interproximal aids as needed. Full mouth bleeding on probing (FMBoP), full mouth plaque score (FMPS), implant bleeding on probing (BoP), implant mean graded bleeding (mBI), implant probing pocket depts (PPD), implant suppuration and bone levels were assessed. Oral health-related Quality of life (OHQoL) and visual analog scales (VAS), which reflect aesthetic satisfaction and pain of the treatment, were also evaluated.

Results

Forty-six patients were included. FMBoP was significantly reduced from 30.1 to 21.5% (test) (p < 0.001) respectively from 35.0% to 30% (control) (p < 0.01). FMPS showed significant reduction from 61.5 to 32.7% (test) (p < 0.001) and from 58.7 to 39.1% (control) (p < 0.001). At the implant BoP reduced from 89.0 to 55.7% (test) (p < 0.001) respectively from 94.9 to 63.7% (control) (p < 0.001). mBI was reduced from 1.3 to 0.6 (test) (p < 0.01) and from 1.9 to 0.8 (control) (p < 0.001). Distribution of "no bleeding" increased from 13 to 61% (test) (p < 0.05) and from 0 to 35% (control) (p < 0.05). At month three, statistically significant intergroup differences were shown for PPD >= 4 mm with 43.5% (test) respectively 73.9% (control) (p < 0.05). At month six, statistically significant intergroup differences, were shown for FMBoP 21.5% (test) respectively 30% (control) (p < 0.05) and for plaque score at the implant 4.0% (test) respectively 26% (control) (p < 0.05). Less pain was reported in the laser group at three days 0.08 (test) respectively 0.2 (control) (p < 0.05).

Conclusions

Treatment of peri-implant mucositis was effective regardless of whether the treatment was performed with an Er:YAG laser or an ultrasonic scaler. Fewer diseased sites were diagnosed at six months following laser treatment.Trial registration: Registered at www.clinicaltrials.gov: study no, NCT05772299. Conclusions Treatment of peri-implant mucositis was effective regardless of whether the treatment was performed with an Er:YAG laser or an ultrasonic scaler. Fewer diseased sites were diagnosed at six months following laser treatment. Trial registration: Registered at www.clinicaltrials.gov: study no, NCT05772299.

Place, publisher, year, edition, pages
Springer-Verlag Tokyo Inc., 2025
Keywords
Er:YAG laser, Patient-reported outcome measures, Peri-implant mucositis, Professional mechanical plaque removal, Ultrasonic scaler
National Category
Dentistry
Identifiers
urn:nbn:se:bth-27448 (URN)10.1186/s40729-025-00591-0 (DOI)001406227500001 ()39853624 (PubMedID)
Note

A correction to this paper has been published:

DOI: 10.1186/s40729-025-00599-6

Available from: 2025-02-11 Created: 2025-02-11 Last updated: 2025-09-30Bibliographically approved
Harrison, P., Madeley, E., Nolan, M., Renvert, S. & Polyzois, I. (2024). A longitudinal analysis of the impact of nonsurgical and surgical treatment of peri-implantitis upon clinical parameters and implant stability quotient values. A 2–3-year follow-up. Clinical and Experimental Dental Research, 10(1), Article ID e833.
Open this publication in new window or tab >>A longitudinal analysis of the impact of nonsurgical and surgical treatment of peri-implantitis upon clinical parameters and implant stability quotient values. A 2–3-year follow-up
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2024 (English)In: Clinical and Experimental Dental Research, E-ISSN 2057-4347, Vol. 10, no 1, article id e833Article in journal (Refereed) Published
Abstract [en]

Objectives: In this study, the aim was to investigate the medium- to long-term impact of peri-implantitis treatment upon clinical parameters and implant stability quotient values and to ascertain if magnetic resonance frequency analysis can be used as a diagnostic tool to demonstrate postoperative healing following treatment of peri-implantitis. Materials and Methods: A total of n = 26 patients (n = 86 implants) diagnosed with peri-implantitis were recruited for this prospective cohort study and four different treatment modalities were used. Baseline measurements of a number of clinical parameters as well as implant stability measurements in the form of ISQ were recorded. These measurements were repeated at 6, 12, and 24–36 months following treatment. Analysis of variance was performed for all implants treated as well as separately for each treatment modality. A regression model was also used to determine factors affecting ISQ measurements over time. Results: Treatment of peri-implantitis resulted in significant improvements of both average PPDs and BOP (p <.0001 and p <.01). ISQ values marginally improved initially for all treatment modalities, but improvement was only maintained for 2–3 years in treatment modalities I (+1.28), III (+1.49), and IV (+2.92). There was a statistically significant negative linear correlation between average PPD and the ISQ values recorded both at baseline (r = −.618, p < 0.0001) and at 2/3 years (r = −.604, p < 0.0001). Conclusion: Over the 2–3-year follow-up period, all four treatment modalities led to improved clinical and radiographic peri-implant parameters but implant stability posttreatment, as indicated by the fact that the recorded ISQ scores remained stable. As a result, use of MRFA as an adjunct to the traditionally used periodontal and radiographic tools for the evaluation of postoperative implant stability following the treatment of peri-implant disease cannot be recommended. © 2023 The Authors. Clinical and Experimental Dental Research published by John Wiley & Sons Ltd.

Place, publisher, year, edition, pages
John Wiley & Sons, 2024
Keywords
dental implants, L-PRF, peri-implantitis, surgical treatment
National Category
Dentistry
Identifiers
urn:nbn:se:bth-25968 (URN)10.1002/cre2.833 (DOI)001156618200001 ()2-s2.0-85183762646 (Scopus ID)
Available from: 2024-02-16 Created: 2024-02-16 Last updated: 2025-09-30Bibliographically approved
Flyborg, J., Idrisoglu, A., Anderberg, P., Renvert, S. & Sanmartin Berglund, J. (2024). Oral Health Parameter-Based Mini-Mental State Examination Indication Using Machine Learning. In: 2024 12th International Conference on Bioinformatics and Computational Biology, ICBCB 2024: . Paper presented at 12th International Conference on Bioinformatics and Computational Biology, ICBCB 2024, Tokyo, March 18-21, 2024 (pp. 113-118). Institute of Electrical and Electronics Engineers (IEEE)
Open this publication in new window or tab >>Oral Health Parameter-Based Mini-Mental State Examination Indication Using Machine Learning
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2024 (English)In: 2024 12th International Conference on Bioinformatics and Computational Biology, ICBCB 2024, Institute of Electrical and Electronics Engineers (IEEE), 2024, p. 113-118Conference paper, Published paper (Refereed)
Abstract [en]

Among the growing elderly population, the number of people with neurocognitive disease increases, highlighting the need for early diagnosis. Mini-Mental State Examination (MMSE) is one of the tools used to diagnose neurocognitive disease. The existence of a relationship between degraded oral health and decreased MMSE scores is known. Using machine Learning (ML) techniques, the present study aimed to study the potential of using oral health and demographic examination data to indicate the level of MMSE score. Data from a study evaluating oral health over time and data from an ongoing study evaluating the general health in an elderly population were used as inputs to ML models Random Forest (RF), Support Vektor Machine (SVM), and Catboost (CB) for the binary indication of MMSE score 30 or MMSE score 26 or lower was used to find the best classification performance to distinguish between MMSE low and healthy control (HC) groups. The classifiers were trained using the nested cross-validation (nCV) method to mitigate the risk of overfiting. CB and RF achieved the highest classification accuracy of 80%. However, the CB classifier outperformed other classifiers with 76.4 average accuracies over all the nCV combinations. The oral health parameters and demographics used as input to the ML classifiers carry enough information to distinguish between MMSE low and HC groups. This study suggests that oral health examination might provide information that can be used with the help of Machine Learning (ML) to indicate lowered MMSE scores.

Place, publisher, year, edition, pages
Institute of Electrical and Electronics Engineers (IEEE), 2024
Keywords
classification, machine learning, mini-mental state examination, neurocognitive disease, oral health data
National Category
Medical Bioinformatics and Systems Biology Oral Health Neurology
Research subject
Applied Health Technology
Identifiers
urn:nbn:se:bth-27927 (URN)10.1109/ICBCB61507.2024.11011974 (DOI)001597076500018 ()2-s2.0-105007737642 (Scopus ID)9798350375749 (ISBN)
Conference
12th International Conference on Bioinformatics and Computational Biology, ICBCB 2024, Tokyo, March 18-21, 2024
Available from: 2025-05-29 Created: 2025-05-29 Last updated: 2025-12-15Bibliographically approved
Critén, S., Andersson, P., Renvert, S., Götrick, B., Sanmartin Berglund, J. & Wallin Bengtsson, V. (2024). Oral Health Status at Age 60 and 72 Years—A Longitudinal Study. International Journal of Dental Hygiene
Open this publication in new window or tab >>Oral Health Status at Age 60 and 72 Years—A Longitudinal Study
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2024 (English)In: International Journal of Dental Hygiene, ISSN 1601-5029, E-ISSN 1601-5037Article in journal (Refereed) Epub ahead of print
Abstract [en]

Objective: This study investigated oral health status in 60-year-old individuals over 12 years.

Materials and Methods: Data were obtained from The Swedish National Study on Aging and Care (SNAC). One hundred nineteen 60-year-old individuals (48% females) underwent a clinical and radiographic baseline examination (2001–2003) and follow-up examination in 2013–2015. For statistical analyses, paired t-tests and McNemar's test were performed. Statistical significance was determined at p < 0.05.

Results: At the 12-year follow-up, the mean number of teeth and the proportion of individuals having ≥ 20 teeth decreased (p < 0.001). The mean number of teeth with buccal/lingual and approximal caries lesions increased (p < 0.029 and p < 0.031). Individuals with a distance from the cement-enamel junction to the bone of ≥ 5 mm increased in total (p < 0.002) and in males (p < 0.006). The prevalence of gingivitis increased in total (p < 0.001). The prevalence of periodontitis showed a significant increase in total (p < 0.043) and in females (p < 0.039).

Conclusion: The present study indicates that oral health status in 60-year-old individuals deteriorates over 12 years. However, the deteriorations were minor in terms of tooth loss, caries lesions, and changes in periodontal status. © 2024 The Author(s). International Journal of Dental Hygiene published by John Wiley & Sons Ltd.

Place, publisher, year, edition, pages
John Wiley & Sons, 2024
Keywords
caries, epidemiology, older persons, oral health, oral health status, periodontal diseases, periodontitis
National Category
Dentistry
Identifiers
urn:nbn:se:bth-27025 (URN)10.1111/idh.12846 (DOI)001336168800001 ()2-s2.0-85206648829 (Scopus ID)
Projects
Swedish National Study on Aging and Care (SNAC)
Available from: 2024-10-25 Created: 2024-10-25 Last updated: 2025-09-30Bibliographically approved
Flyborg, J., Renvert, S., Anderberg, P., Larsson, T. & Sanmartin Berglund, J. (2024). Results of objective brushing data recorded from a powered toothbrush used by elderly individuals with mild cognitive impairment related to values for oral health. Clinical Oral Investigations, 28(1), Article ID 8.
Open this publication in new window or tab >>Results of objective brushing data recorded from a powered toothbrush used by elderly individuals with mild cognitive impairment related to values for oral health
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2024 (English)In: Clinical Oral Investigations, ISSN 1432-6981, E-ISSN 1436-3771, Vol. 28, no 1, article id 8Article in journal (Refereed) Published
Abstract [en]

Objectives: The study aimed to investigate how the objective use of a powered toothbrush in frequency and duration affects plaque index, bleeding on probing, and periodontal pocket depth ≥ 4 mm in elderly individuals with MCI. A second aim was to compare the objective results with the participants’ self-estimated brush use.

Materials and methods: Objective brush usage data was extracted from the participants’ powered toothbrushes and related to the oral health variables plaque index, bleeding on probing, and periodontal pocket depth ≥ 4 mm. Furthermore, the objective usage data was compared with the participants’ self-reported brush usage reported in a questionnaire at baseline and 6- and 12-month examination.

Results: Out of a screened sample of 213 individuals, 170 fulfilled the 12-month visit. The principal findings are that despite the objective values registered for frequency and duration being lower than the recommended and less than the instructed, using powered toothbrushes after instruction and information led to improved values for PI, BOP, and PPD ≥ 4 mm in the group of elderly with MIC.

Conclusions: Despite lower brush frequency and duration than the generally recommended, using a powered toothbrush improved oral health. The objective brush data recorded from the powered toothbrush correlates poorly with the self-estimated brush use. Clinical relevance: Using objective brush data can become one of the factors in the collaboration to preserve and improve oral health in older people with mild cognitive impairment.

Trial registration: ClinicalTrials.gov Identifier: NCT05941611, retrospectively registered 11/07/2023. © 2023, The Author(s).

Place, publisher, year, edition, pages
Springer Science+Business Media B.V., 2024
Keywords
Elderly individuals, Mild cognitive impairment, Oral health, Powered toothbrush
National Category
Dentistry
Identifiers
urn:nbn:se:bth-25835 (URN)10.1007/s00784-023-05407-2 (DOI)001132641500001 ()2-s2.0-85180240432 (Scopus ID)
Available from: 2023-12-30 Created: 2023-12-30 Last updated: 2025-09-30Bibliographically approved
Henricsson, S., Wallin Bengtsson, V., Renvert, S., Sanmartin Berglund, J., Lundegren, N. & Andersson, P. (2024). Self-perceived oral health and orofacial appearance in an adult population, 60 years of age. International Journal of Dental Hygiene, 22(3), 575-587
Open this publication in new window or tab >>Self-perceived oral health and orofacial appearance in an adult population, 60 years of age
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2024 (English)In: International Journal of Dental Hygiene, ISSN 1601-5029, E-ISSN 1601-5037, Vol. 22, no 3, p. 575-587Article in journal (Refereed) Published
Abstract [en]

Objective: The study aimed to compare self-perceived oral health and orofacial appearance in three different cohorts of 60-year-old individuals. Method: A cross-sectional design, based on data obtained from a questionnaire used in the Swedish National Study of Aging and Care. The sample comprised 478 individuals, from baseline, 2001–2003 (n = 191), 2007–2009 (n = 218) and 2014–2015 (n = 69). Comparisons were made within and between the cohorts, with bivariate analysis and Fisher's exact test. Statistical significance was considered at p < 0.05. Results: The result showed that a low number of the participants reported self-perceived problems with oral health. Of the problems reported, a higher proportion in cohort 2014–2015 (39.3%) experienced problems with bleeding gums. The experience of bleeding gums increased between the cohorts 2001–2003 and 2014–2015 (p = 0.040) and between 2007–2009 and 2014–2015 (p = 0.017). The prevalence of discomfort with sensitive teeth was experienced in 7%–32%. Twice as many women compared to men experienced discomfort in all cohorts (no significant differences between the cohorts). Satisfaction with dental appearance was experienced in 75%–84%. Twice as many women compared to men were dissatisfied with their dental appearance in 2001–2003 (p = 0.011) and with discoloured teeth (p = 0.020). No significant differences could be seen between the cohorts regarding discomfort with dental appearance or discoloured teeth. Conclusion: The 60-year-olds irrespective of birth cohort, perceived their oral health and orofacial appearance as satisfactory. © 2023 The Authors. International Journal of Dental Hygiene published by John Wiley & Sons Ltd.

Place, publisher, year, edition, pages
John Wiley & Sons, 2024
Keywords
appearance, older adults, oral health, orofacial, self-perceived
National Category
Dentistry
Identifiers
urn:nbn:se:bth-25208 (URN)10.1111/idh.12711 (DOI)001020957000001 ()2-s2.0-85162987983 (Scopus ID)
Projects
SNAC
Available from: 2023-08-06 Created: 2023-08-06 Last updated: 2025-09-30Bibliographically approved
Henricsson, S., Wallin Bengtsson, V., Renvert, S., Sanmartin Berglund, J., Lundegren, N. & Andersson, P. (2024). Self-perceived oral health and orofacial appearance in older adults - an 18-year follow-up study in Karlskrona, Sweden. Acta Odontologica Scandinavica, 83, 255-263
Open this publication in new window or tab >>Self-perceived oral health and orofacial appearance in older adults - an 18-year follow-up study in Karlskrona, Sweden
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2024 (English)In: Acta Odontologica Scandinavica, ISSN 0001-6357, E-ISSN 1502-3850, Vol. 83, p. 255-263Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: To analyze whether self-perceived oral health and orofacial appearance change with increasing age.

METHODS: This longitudinal study is based on data from a questionnaire used in the Swedish National Study of Aging and Care. The sample comprises 160 participants 60 years of age at baseline 2001-2003. The same participants were re-examined at 66-, 72-, and 78 years of age. To analyze whether perceptions of oral health and orofacial appearance changed with increasing age, Cochran's Q test was conducted. Statistical significance was considered at p  ≤  0.05, and the calculated value Q must be equal to or greater than the critical chi-square value (Q ≥ 7.82). Significance values have been adjusted for the Bonferroni correction for multiple tests.

RESULTS: Self-perceived mouth dryness, both day (Q = 7.94) and night (Q = 23.41), increased over the 18-year follow-up. When divided by gender, significant differences were only seen for mouth dryness at nighttime. A decrease in sensitive teeth was perceived with increasing age, and an increase in self-perceived satisfaction with dental appearance, and a decrease in self-perceived problems with dental gaps between the ages of 60 and 78. These changes were, however, not statistically significant. Men experienced a higher proportion of discomfort with discolored teeth at age 78 than at 60 (Q = 9.09).

CONCLUSIONS: Self-perceived oral health and orofacial appearance were relatively stable, with few changes over an 18-year follow-up.

Place, publisher, year, edition, pages
MJS publishing, 2024
Keywords
Aged, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Oral Health, Self Concept, Surveys and Questionnaires, Sweden, follow up, health, human, longitudinal study, questionnaire
National Category
Dentistry
Identifiers
urn:nbn:se:bth-26192 (URN)10.2340/aos.v83.40574 (DOI)001267523400009 ()38700368 (PubMedID)2-s2.0-85192044617 (Scopus ID)
Available from: 2024-05-15 Created: 2024-05-15 Last updated: 2025-09-30Bibliographically approved
Renvert, S., Giovannoli, J.-L. & Rinke, S. (2024). The efficacy of reconstructive therapy in the surgical management of peri-implantitis: A 3-year follow-up of a randomized clinical trial. Journal of Clinical Periodontology, 51(10), 1267-1276
Open this publication in new window or tab >>The efficacy of reconstructive therapy in the surgical management of peri-implantitis: A 3-year follow-up of a randomized clinical trial
2024 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 51, no 10, p. 1267-1276Article in journal (Refereed) Published
Abstract [en]

Aim: To assess whether guided bone regeneration (GBR) treatment of peri-implantitis-related bony defects could improve healing compared to open flap debridement (OFD) at 36 months. Materials and Methods: In a multi-centre, randomized clinical trial, 32 individuals received OFD (control group [CG]) and 34 GBR treatment (test group [TG]). Radiographic defect fill (RDF), probing pocket depth (PPD), bleeding on probing (BOP) suppuration (SUP), mucosal recession (MREC) and patient-reported outcomes (PROs) were evaluated at 36 months. Results: Fifty individuals attended a supportive peri-implant therapy program and completed the 36-month follow-up. GBR treatment resulted in an RDF of 2.13 ± 1.26 mm compared to 1.64 ± 1.54 mm following OFD (p =.18). No difference was found in PPD, BOP, SUP, REC or PROs between the groups. Successful treatment (no additional bone loss, PPD ≤ 5 mm, no BOP and no SUP) was achieved in 46.2% in TG and 20% in CG (p =.053). Treatment results obtained at 12 months were generally maintained up to 36 months. No significant changes were noticed between 12 and 36 months. Conclusions: At 36 months, treatment results obtained at 1 year were sustained following both GBR and OFD in patients attending supportive peri-implant therapy. GBR resulted in more RDF and higher composite treatment success rate than OFD (ClinicalTrials.gov Identifier [NCT02375750]). © 2024 The Author(s). Journal of Clinical Periodontology published by John Wiley & Sons Ltd.

Place, publisher, year, edition, pages
John Wiley & Sons, 2024
Keywords
bone augmentation, bone substitute, native bilayer collagen membrane, peri-implantitis, surgical treatment
National Category
Dentistry
Identifiers
urn:nbn:se:bth-26777 (URN)10.1111/jcpe.14049 (DOI)001270317000001 ()39020503 (PubMedID)2-s2.0-85198733221 (Scopus ID)
Available from: 2024-08-09 Created: 2024-08-09 Last updated: 2025-09-30Bibliographically approved
Flyborg, J., Renvert, S., Anderberg, P. & Sanmartin Berglund, J. (2024). The long-term effect on oral health and quality of life using a powered toothbrush in individuals with mild cognitive impairment. An intervention trial. Special Care in Dentistry: managing special patients, settings, and situations, 44(6), 1700-1708
Open this publication in new window or tab >>The long-term effect on oral health and quality of life using a powered toothbrush in individuals with mild cognitive impairment. An intervention trial
2024 (English)In: Special Care in Dentistry: managing special patients, settings, and situations, ISSN 0275-1879, E-ISSN 1754-4505, Vol. 44, no 6, p. 1700-1708Article in journal (Refereed) Published
Abstract [en]

Background: The number of older individuals with mild cognitive impairment and neurocognitive diseases is increasing, which may rapidly deteriorate oral health and Quality of life. Therefore, removing dental biofilm is essential for maintaining good oral health. The present study aimed to investigate whether introducing a powered toothbrush reduces the presence of dental plaque, bleeding on probing, and periodontal pockets ≥4 mm, leading to maintained or improved oral health and improved Quality of life in a group of older individuals with mild cognitive impairment. Methods: Two hundred and thirteen individuals aged 55 or older living without official home care with a Mini–Mental State Examination (MMSE) score between 20 and 28 and a history of memory problems in the previous 6 months were recruited and screened for the study. The individuals received a powered toothbrush and thorough instructions on how to use it. Clinical oral examinations, Quality of life examinations, and MMSE tests were conducted at baseline, 6, 12, and 24 months. The intervention group was compared to control groups at baseline and 24-month examination. It was divided into an MMSE high group with a score of more than 26 and an MMSE low group with a score of 26 and lower or decreasing two steps or more for 12 months. Results: PI, BOP, and PPD≥4 mm improved continuously in both MMSE groups during the 24 months of the study. The values for QoL-AD deteriorated over time, while the oral health-related Quality of life did not show any statistically significant changes. Conclusions: Introducing a powered toothbrush improved PI, BOP, and PPD≥4 mm over 24 months, even among individuals with low or declining MMSE scores. Improved oral health is associated with a preserved OHR-QoL. © 2024 The Author(s). Special Care in Dentistry published by Special Care Dentistry Association and Wiley Periodicals LLC.

Place, publisher, year, edition, pages
John Wiley & Sons, 2024
Keywords
mild cognitive impairment, oral health, powered toothbrush, quality of life
National Category
Dentistry
Identifiers
urn:nbn:se:bth-26767 (URN)10.1111/scd.13040 (DOI)001269200200001 ()38994574 (PubMedID)2-s2.0-85198070408 (Scopus ID)
Available from: 2024-08-08 Created: 2024-08-08 Last updated: 2025-09-30Bibliographically approved
Svärd, A., Kastbom, A., Roos Ljungberg, K., Potempa, B., Potempa, J., Persson, G. R., . . . Söderlin, M. K. (2023). Antibodies against Porphyromonas gingivalis in serum and saliva and their association with rheumatoid arthritis and periodontitis: Data from two rheumatoid arthritis cohorts in Sweden. Frontiers in Immunology, 14, Article ID 1183194.
Open this publication in new window or tab >>Antibodies against Porphyromonas gingivalis in serum and saliva and their association with rheumatoid arthritis and periodontitis: Data from two rheumatoid arthritis cohorts in Sweden
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2023 (English)In: Frontiers in Immunology, E-ISSN 1664-3224, Vol. 14, article id 1183194Article in journal (Refereed) Published
Abstract [en]

Background: Periodontitis and oral pathogenic bacteria can contribute to the development of rheumatoid arthritis (RA). A connection between serum antibodies to Porphyromonas gingivalis (P. gingivalis) and RA has been established, but data on saliva antibodies to P. gingivalis in RA are lacking. We evaluated antibodies to P. gingivalis in serum and saliva in two Swedish RA studies as well as their association with RA, periodontitis, antibodies to citrullinated proteins (ACPA), and RA disease activity. Methods: The SARA (secretory antibodies in RA) study includes 196 patients with RA and 101 healthy controls. The Karlskrona RA study includes 132 patients with RA ≥ 61 years of age, who underwent dental examination. Serum Immunoglobulin G (IgG) and Immunoglobulin A (IgA) antibodies and saliva IgA antibodies to the P. gingivalis–specific Arg-specific gingipain B (RgpB) were measured in patients with RA and controls. Results: The level of saliva IgA anti-RgpB antibodies was significantly higher among patients with RA than among healthy controls in multivariate analysis adjusted for age, gender, smoking, and IgG ACPA (p = 0.022). Saliva IgA anti-RgpB antibodies were associated with RA disease activity in multivariate analysis (p = 0.036). Anti-RgpB antibodies were not associated with periodontitis or serum IgG ACPA. Conclusion: Patients with RA had higher levels of saliva IgA anti-RgpB antibodies than healthy controls. Saliva IgA anti-RgpB antibodies may be associated with RA disease activity but were not associated with periodontitis or serum IgG ACPA. Our results indicate a local production of IgA anti-RgpB in the salivary glands that is not accompanied by systemic antibody production. Copyright © 2023 Svärd, Kastbom, Ljungberg, Potempa, Potempa, Persson, Renvert, Berglund and Söderlin.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2023
Keywords
anti-citrullinated antibodies (ACPAs), gingipain and periodontitis, periodontitis, porphyromonas gingivalis, rheumatoid arthritis, saliva
National Category
Clinical Medicine Dentistry
Identifiers
urn:nbn:se:bth-25062 (URN)10.3389/fimmu.2023.1183194 (DOI)001006380100001 ()2-s2.0-85162055082 (Scopus ID)
Funder
Region BlekingeThe Crafoord FoundationSwedish Rheumatism Association
Available from: 2023-06-30 Created: 2023-06-30 Last updated: 2025-09-30Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-0992-2362

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