We study Ore extensions of non-unital associative rings. We provide a characterization of simple non-unital differential polynomial rings R[x; delta], under the hy-pothesis that R is s-unital and ker(delta) contains a non-zero idempotent. This result gener-alizes a result by oinert, Richter and Silvestrov from the unital setting. We also present a family of examples of simple non-unital differential polynomial rings.