The 'Human-Centered Intelligent Realities' (HINTS) laboratory is a strategic infrastructure project aiming to support research that advances the development of immersive, user-aware, and intelligent digital environments by integrating augmented reality (AR), virtual reality (VR), extended reality (XR), artificial intelligence (AI), and machine learning (ML). By combining virtual reality and communication-computing continuums, the HINTS environment seeks to create innovative concepts, methods, and tools that empower users to engage with digital systems in novel, efficient, and effective ways. Research in the HINTS laboratory focuses on experience assessment, new digital environments and interaction techniques, visual analytics, adaptive AI, and networking. This paper presents the HINTS laboratory, ongoing activities, and opportunities and challenges for the future.